KLF2 prevents aberrant CD8 T cell differentiation in acute LCMV infection.

Naïve CD8 T cells undergo functional effector differentiation in acute LCMV infection. This effector differentiation involves KLF2-dependent TBET activity. KLF2 KO in this setting results in aberrant CD8 T cell differentiation to a TOX+ exhausted-like state. This is characterized by an epigenetic and transcriptional signature resembling hallmark features of CD8 T cells in chronic infection and results in reduced cytolytic potential and memory recall capacity. [Figure created with BioRender.com]

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