Impact of tumor microenvironment on immune response
Pancreatic ductal adenocarcinoma is the most common form of pancreatic cancer and is defined by its dense, desmoplastic stroma. This stroma is thought to modulate the efficacy of therapy and potentially anti-tumor immune responses, but how this occurs is less well understood. Our team has developed novel models of pancreatic cancer to investigate the mechanisms for how this complex microenvironment impacts immune cell function.
This work was supported by a generous donation from Mr. J. Leschly and a grant from the Foley Foundation.